Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

The dopaminergic system is a central component of the brain's neurobiological framework,
governing motor control and reward responses and playing an essential role in various …

Measuring the real-time dynamics of neuromodulator release in the brain with subcellular
resolution is a long-sought goal in neuroscience, due to the immense implications for basic …

Computational modeling of dopamine transmission is challenged by complex underlying
mechanisms. Here we present a new computational model that (I) simultaneously regards …

A wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode
of signaling, often called volume transmission, differs from classical synaptic transmission in …

Neural activity is finely tuned to produce normal behaviors, and disruptions in activity likely
occur early in the course of many neurodegenerative diseases. However, how neural activity …

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental
disorder in children. Although the involvement of dopamine in this disorder seems to be …

Most physiologic processes in the brain and related diseases involve more than one
neurotransmitter system. Thus, elucidation of the interaction between different …

The catecholamine, dopamine, plays an important role in the central nervous system of
mammals, including executive functions, motor control, motivation, arousal, reinforcement …