Why do RNA viruses recombine?

E Simon-Loriere, EC Holmes - Nature Reviews Microbiology, 2011 - nature.com
Recombination occurs in many RNA viruses and can be of major evolutionary significance.
However, rates of recombination vary dramatically among RNA viruses, which can range …

Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease

DM Tebit, EJ Arts - The Lancet infectious diseases, 2011 - thelancet.com
Since the isolation of HIV, multiple transmissions are thought to have occurred between man
and other old-world primates. Assessment of samples from apes and human beings with …

COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification

D Struck, G Lawyer, AM Ternes, JC Schmit… - Nucleic acids …, 2014 - academic.oup.com
Viral sequence classification has wide applications in clinical, epidemiological, structural
and functional categorization studies. Most existing approaches rely on an initial alignment …

The origin of genetic diversity in HIV-1

RP Smyth, MP Davenport, J Mak - Virus research, 2012 - Elsevier
One of the hallmarks of HIV infection is the rapid development of a genetically complex
population (quasispecies) from an initially limited number of infectious particles. Genetic …

The remarkable frequency of human immunodeficiency virus type 1 genetic recombination

A Onafuwa-Nuga, A Telesnitsky - Microbiology and Molecular …, 2009 - Am Soc Microbiol
The genetic diversity of human immunodeficiency virus type 1 (HIV-1) results from a
combination of point mutations and genetic recombination, and rates of both processes are …

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

H Song, EE Giorgi, VV Ganusov, F Cai… - Nature …, 2018 - nature.com
Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of
within-host diversification is less understood. Here we develop a novel computational tool …

Viral reverse transcriptases

L Menéndez-Arias, A Sebastián-Martín, M Álvarez - Virus research, 2017 - Elsevier
Reverse transcriptases (RTs) play a major role in the replication of Retroviridae,
Metaviridae, Pseudoviridae, Hepadnaviridae and Caulimoviridae. RTs are enzymes that are …

Mechanisms and factors that influence high frequency retroviral recombination

K Delviks-Frankenberry, A Galli, O Nikolaitchik, H Mens… - Viruses, 2011 - mdpi.com
With constantly changing environmental selection pressures, retroviruses rely upon
recombination to reassort polymorphisms in their genomes and increase genetic diversity …

Complex recombination patterns arising during geminivirus coinfections preserve and demarcate biologically important intra-genome interaction networks

DP Martin, P Lefeuvre, A Varsani, M Hoareau… - PLoS …, 2011 - journals.plos.org
Genetic recombination is an important process during the evolution of many virus species
and occurs particularly frequently amongst begomoviruses in the single stranded DNA virus …

[HTML][HTML] Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses

M Nikolaidis, K Mimouli, Z Kyriakopoulou, M Tsimpidis… - Virology, 2019 - Elsevier
Recombination is a driving force for the emergence, evolution and virulence/epidemics of
viruses, comprising the Enterovirus genus of the Picornaviridae family, important for human …