Abstract During SARS-CoV-2 infection, the innate immune response can be inhibited or
delayed, and the subsequent persistent viral replication can induce emergency signals that …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …

Patients with essential thrombocythemia may carry JAK2 (V617F), an MPL substitution, or a
calreticulin gene (CALR) mutation. We studied biologic and clinical features of essential …

We studied the impact of driver mutations of JAK2, CALR,(calreticulin gene) or MPL on
clinical course, leukemic transformation, and survival of patients with primary myelofibrosis …

A quarter of patients with essential thrombocythemia or primary myelofibrosis carry a driver
mutation of CALR, the calreticulin gene. A 52-bp deletion (type 1) and a 5-bp insertion (type …

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core
component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS) …

Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and
calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). From …

A well-functioning hematopoietic system requires a certain robustness and flexibility to
maintain appropriate quantities of functional mature blood cells, such as red blood cells and …

Since the discovery of the JAK 2 V617F mutation in the majority of the myeloproliferative
neoplasms (MPN) of polycythemia vera, essential thrombocythemia and primary …

We studied mutations of MPL exon 10 in patients with essential thrombocythemia (ET) or
primary myelofibrosis (PMF), first investigating a cohort of 892 consecutive patients. MPL …