Integral membrane proteins (IMPs) play central roles in cellular physiology and represent
the majority of known drug targets. Single-molecule fluorescence and fluorescence …

Single-molecule fluorescence imaging experiments generally require sub-nanomolar
protein concentrations to isolate single protein molecules, which makes such experiments …

Plasmonic optical nanoantennas offer compelling solutions for enhancing light–matter
interactions at the nanoscale. However, until now, their focus has been mainly limited to the …

Gold nanoclusters (AuNCs) have captured significant interest for their photoluminescent
properties; however, their rapid photodynamics remain elusive while probed by ensemble …

In stochastic blocking electrochemistry, adsorptive collisions of nano and micro-particles
with an ultramicroelectrode (UME) generate steps of decreasing current overlaid on the …

The reactivation of heterotrimeric protein phosphatase 2A (PP2A) through small molecule
activators is of interest to therapeutic intervention due to its dysregulation, which is linked to …

Creating increasingly sensitive and cost-effective nucleic acid detection methods is critical
for enhancing point-of-care (POC) applications. This involves capturing all desired …

A main limitation of single-molecule fluorescence (SMF) measurements is the" high
concentration barrier", describing the maximum concentration of fluorescent species …

In the human heart, the binding of cyclic adenosine monophosphate (cAMP), a second
messenger, to hyperpolarization and cyclic nucleotide-gated (HCN) regulates the …

Single-molecule fluorescence imaging has extensively revealed the dynamic and structural
characteristics of biomolecules. However, its application is limited by the upper …