Glutamine reliance in cell metabolism
As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …
From Krebs to clinic: glutamine metabolism to cancer therapy
The resurgence of research into cancer metabolism has recently broadened interests
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …
beyond glucose and the Warburg effect to other nutrients, including glutamine. Because …
The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies
J Wang, Y Chen, H Zhong, F Chen… - Critical Reviews in …, 2022 - Taylor & Francis
Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA)
metabolism, which is a complex physiological process involving multiple organs (liver …
metabolism, which is a complex physiological process involving multiple organs (liver …
Aspartate is an endogenous metabolic limitation for tumour growth
LB Sullivan, A Luengo, LV Danai, LN Bush… - Nature cell …, 2018 - nature.com
Defining the metabolic limitations of tumour growth will help to develop cancer therapies.
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …
Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that …
Similarities and distinctions of cancer and immune metabolism in inflammation and tumors
G Andrejeva, JC Rathmell - Cell metabolism, 2017 - cell.com
It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …
resting tissues. More recently understood is that this metabolic phenotype is not unique to …
Rewiring urea cycle metabolism in cancer to support anabolism
Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the
anabolic synthesis of macromolecules that are required during tumour proliferation and …
anabolic synthesis of macromolecules that are required during tumour proliferation and …
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA)
cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on …
cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on …
Advancing cancer treatment by targeting glutamine metabolism—A roadmap
Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …
Targeting pyrimidine metabolism in the era of precision cancer medicine
W Wang, J Cui, H Ma, W Lu, J Huang - Frontiers in oncology, 2021 - frontiersin.org
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …
Selenium deficiency-induced multiple tissue damage with dysregulation of immune and redox homeostasis in broiler chicks under heat stress
L Zhao, M Liu, H Sun, JC Yang, YX Huang… - Science China Life …, 2023 - Springer
Broiler chicks are fast-growing and susceptible to dietary selenium (Se) deficiency. This
study sought to reveal the underlying mechanisms of how Se deficiency induces key organ …
study sought to reveal the underlying mechanisms of how Se deficiency induces key organ …