Tissue engineering of bone and cartilage has progressed from simple to sophisticated
materials with defined porosity, surface features, and the ability to deliver biological factors …

Cell-based therapy represents a promising treatment strategy for cartilage defects. Alone or
in combination with scaffolds/biological signals, these strategies open many new avenues …

The native extracellular matrix (ECM) is a complex gel-like system with a broad range of
structural features and biomolecular signals. Hydrogel platforms that can recapitulate the …

Articular cartilage defects have very limited self-repair potential, and traditional bone marrow-
stimulating therapy is not effective. Cartilage tissue engineering using bone marrow …

Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists
due to the lack of available drugs reducing structural degradation. Mesenchymal stromal …

Post-traumatic and focal cartilage defects of the knee affect over 3 million Americans
annually. Autologous cell-based cartilage repair, for example, autologous chondrocyte …

Representing a strategy of marine by-products valorization, based on isolation of
biocompounds and assessment of biomedical applicability, the potential of blue shark …

CD271 is a marker of bone marrow MSCs with enhanced differentiation capacity for bone or
cartilage repair. However, the nature of CD271+ MSCs from adipose tissue (AT) is less well …

Chondral defects are frequent and important causes of pain and disability. Cartilage has
limited self-repair and regeneration capacity. The ideal approach for articular cartilage …

Over the past two decades, there has been an explosion in the numbers of clinical trials
using mesenchymal stem cells (MSCs). While the safety profile of MSC therapy has been …