We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …

Studying the stress response is a major pillar of neuroscience research not only because
stress is a daily reality but also because the exquisitely fine-tuned bodily changes triggered …

Understanding any brain circuit will require a categorization of its constituent neurons. In
hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to …

Activity-driven transcription plays an important role in many brain processes, including those
underlying memory and epilepsy. Here we combine genetic tagging of nuclei and ribosomes …

Within eukaryotic cells, translation is regulated independent of transcription, enabling
nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally and …

Accumulating evidence indicates that some protein-coding genes have originated de novo
from previously non-coding genomic sequences. However, the processes underlying de …

Sparse populations of neurons in the dentate gyrus (DG) of the hippocampus are causally
implicated in the encoding of contextual fear memories. However, engram-specific …

Computational methods have been proposed to leverage spatially resolved transcriptomic
data, pinpointing genes with spatial expression patterns and delineating tissue domains …

Stressful experiences are part of everyday life and animals have evolved physiological and
behavioral responses aimed at coping with stress and maintaining homeostasis. However …

Huntington's disease (HD) is a neurodegenerative disorder caused by expansion of a CAG
trinucleotide repeat in the Huntingtin (HTT) gene, encoding a homopolymeric polyglutamine …