Compositional assessment of bone by Raman spectroscopy
Raman spectroscopy (RS) is used to analyze the physiochemical properties of bone
because it is non-destructive and requires minimal sample preparation. With over two …
because it is non-destructive and requires minimal sample preparation. With over two …
Causative or associative: A critical review of the role of advanced glycation end-products in bone fragility
TL Willett, P Voziyan, JS Nyman - Bone, 2022 - Elsevier
The accumulation of advanced glycation end-products (AGEs) in the organic matrix of bone
with aging and chronic disease such as diabetes is thought to increase fracture risk …
with aging and chronic disease such as diabetes is thought to increase fracture risk …
Bone hydration: How we can evaluate it, what can it tell us, and is it an effective therapeutic target?
Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …
mechanical properties and tissue quality. There is a growing appreciation for how water can …
Advanced glycation and glycoxidation end products in bone
B Wang, D Vashishth - Bone, 2023 - Elsevier
Hyperglycemia and oxidative stress, enhanced in diabetes and aging, result in excessive
accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone …
accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone …
Sensitivity of the amide I band to matrix manipulation in bone: a Raman micro-spectroscopy and spatially offset Raman spectroscopy study
The fracture resistance of bone arises from the hierarchical arrangement of minerals,
collagen fibrils (ie, cross-linked triple helices of α1 and α2 collagen I chains), non …
collagen fibrils (ie, cross-linked triple helices of α1 and α2 collagen I chains), non …
Induction and rescue of skeletal fragility in a high-fat diet mouse model of type 2 diabetes: An in vivo and in vitro approach
Poor bone quality is associated with Type 2 Diabetes (T2D), with patients having a higher
risk of fracture despite normal to high bone mineral density (BMD). Diabetes contributes to …
risk of fracture despite normal to high bone mineral density (BMD). Diabetes contributes to …
The age-related decrease in material properties of BALB/c mouse long bones involves alterations to the extracellular matrix
One possibility for the disproportionate increase in fracture risk with aging relative to the
decrease in bone mass is an accumulation of changes to the bone matrix which …
decrease in bone mass is an accumulation of changes to the bone matrix which …
Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality
Since spatially offset Raman spectroscopy (SORS) can acquire biochemical measurements
of tissue quality through light scattering materials, we investigated the feasibility of this …
of tissue quality through light scattering materials, we investigated the feasibility of this …
Bone intrinsic material and compositional properties in postmenopausal women diagnosed with long-term Type-1 diabetes
W Qian, S Gamsjaeger, EP Paschalis, LA Graeff-Armas… - Bone, 2023 - Elsevier
The incidence of diabetes mellitus and the associated complications are growing worldwide,
affecting the patients' quality of life and exerting a considerable burden on health systems …
affecting the patients' quality of life and exerting a considerable burden on health systems …
Effect of ribose incubation on physical, chemical, and mechanical properties of human cortical bone
Raman spectroscopy (RS) is sensitive to the accumulation of advanced glycation end-
products (AGEs), and it measures matrix-sensitive properties that correlate with the fracture …
products (AGEs), and it measures matrix-sensitive properties that correlate with the fracture …