It took more than 100 years before it was established that the proteins that form intermediate
filaments (IFs) comprise a unified protein family, the members of which are ubiquitous in …

Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …

Keratins 8 (K8) and 18 (K18) are major components of intermediate filaments (IFs) of simple
epithelial cells and tumors derived from such cells. Structural cell changes during apoptosis …

Previously we demonstrated that transgenic mice expressing mutant basal epidermal keratin
genes exhibited a phenotype resembling a group of autosomal dominant human skin …

This study describes the development and use of a specific method for disassembling
intermediate filament (IF) networks in living cells. It takes advantage of the disruptive effects …

Keratins are the major structural proteins of the vertebrate epidermis and its appendages,
constituting up to 85% of a fully differentiated keratinocyte. Together with actin …

IN the hereditary blistering condition epidermolysis bullosa simplex, the skin blisters on
trauma following rupture of epidermal basal cells. Clinical variations range from severely …

The epidermis is the stratified squamous epithelium that forms the outer covering of the skin.
The major epidermal cell type is the keratinocyte; other epidermal cells are melanocytes …

Epidermolysis bullosa simplex (EBS) is characterized by skin blistering due to basal
keratinocyte fragility. In one family studied, inheritance of EBS is linked to the gene encoding …

Epidermolysis bullosa (EB) simplex is a rare genetic condition typified by superficial bullous
lesions that result from frictional trauma to the skin. Most cases are due to dominantly acting …