Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Nanoinformatics and nanotechnology in anti-inflammatory therapy: A review

AK Mishra, L Rani, R Singh, HK Dewangan… - Journal of Drug Delivery …, 2024 - Elsevier
A necessary immune response that promotes survival and preserves tissue homeostasis,
inflammation is a frequent characteristic of many disorders. In other circumstances, however …

Synthesis, biological evaluation and 3D-QSAR study of novel 4, 5-dihydro-1H-pyrazole thiazole derivatives as BRAFV600E inhibitors

MY Zhao, Y Yin, XW Yu, CB Sangani, SF Wang… - Bioorganic & medicinal …, 2015 - Elsevier
Many reports implied that the BRAF serine/threonine kinase was mutated in various types of
human tumors, which were related with cell growth, survival and differentiation. To provide …

Salivary proteomics and biomarkers in neurology and psychiatry

KL Wormwood, R Aslebagh… - PROTEOMICS …, 2015 - Wiley Online Library
Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective
and earlier diagnoses of CNS conditions. Proteomics and other omics MS‐based …

The potential of biomarkers in psychiatry: focus on proteomics

I Sokolowska, AG Ngounou Wetie… - Journal of Neural …, 2015 - Springer
The etiology and pathogenesis of many psychiatric disorders are unclear with many
signaling pathways and complex interactions still unknown. Primary information provided …

Mass spectrometry for the detection of potential psychiatric biomarkers

AG Ngounou Wetie, I Sokolowska… - Journal of Molecular …, 2013 - Springer
The search for molecules that can act as potential biomarkers is increasing in the scientific
community, including in the field of psychiatry. The field of proteomics is evolving and its …

Mass spectrometry as a tool for studying autism spectrum disorder

AG Woods, AG Ngounou Wetie, I Sokolowska… - Journal of Molecular …, 2013 - Springer
Autism spectrum disorders (ASDs) are increasing in incidence but have an incompletely
understood etiology. Tools for uncovering clues to the cause of ASDs and means for …

Structural characterizations of the fas receptor and the fas-associated protein with death domain interactions

U Roy - The Protein Journal, 2016 - Springer
The Fas receptor is a representative death receptor, and the Fas-associated protein with
death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's …

Mass spectrometry investigation of glycosylation on the NXS/T sites in recombinant glycoproteins

I Sokolowska, AGN Wetie, U Roy, AG Woods… - … et Biophysica Acta (BBA …, 2013 - Elsevier
We used a targeted proteomics approach to investigate whether introduction of new N-
linked glycosylation sites in a chimeric protein influence the glycosylation of the existing …

Structural modeling of tumor necrosis factor: A protein of immunological importance

U Roy - Biotechnology and Applied Biochemistry, 2017 - Wiley Online Library
Tumor necrosis factor (TNF) is a multifunctional pro‐inflammatory cytokine responsible for
various immunoregulatory activities. Upon binding with its receptor, TNF triggers multiple …