Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

In recent years, a significant amount of research has examined the controversial role of
activin A in cancer. Activin A, a member of the transforming growth factor β (TGFβ) …

Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting
primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

BACKGROUND Understanding the molecular and cellular mechanisms of human
reproductive development has been limited by the scarcity of human samples and ethical …

This prospective study evaluated the accuracy of non-invasive preimplantation genetic
testing for aneuploidy (niPGT-A) using cell-free DNA in spent culture medium, as well as that …

Abstract miRNAs are short, noncoding RNAs that regulate expression of target genes at post-
transcriptional levels and function in many important cellular processes, including …

Understanding the regulatory networks for germ cell fate specification is necessary to
developing strategies for improving the efficiency of germ cell production in vitro. In this …

Human embryonic stem cells (hESCs) derived in the presence of Activin A (ActA)
demonstrate an increased differentiation propensity toward the germ cell lineage. In …

Our current knowledge of the mechanisms leading to human primordial germ cell (PGC)
specification stems solely from differentiation experiments starting from human pluripotent …