Double‐strand breaks (DSBs) are the most deleterious DNA lesions, which, if left
unrepaired, may have severe consequences for cell survival, as they lead to chromosome …

When DNA damage, whether it is endogenous or exogenous, forms double stranded breaks
(DSBs), it is always followed by the phosphorylation of the histone, H2AX. H2AX is a variant …

Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …

Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …

Epithelial–mesenchymal transition (EMT) is associated with characteristics of breast cancer
stem cells, including chemoresistance and radioresistance. However, it is unclear whether …

DNA double-strand breaks (DSBs) are extremely dangerous lesions with severe
consequences for cell survival and the maintenance of genomic stability. In higher …

Background Preclinical evidence shows that short-term fasting (STF) protects healthy cells
against side effects of chemotherapy and makes cancer cells more vulnerable to it. This pilot …

One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …

DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …

Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant,
H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is …