Inner hair cell loss disrupts hearing and cochlear function leading to sensory deprivation and enhanced central auditory gain

R Salvi, W Sun, D Ding, GD Chen… - Frontiers in …, 2017 - frontiersin.org
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC
transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I …

Hyperacusis: Loudness intolerance, fear, annoyance and pain

R Salvi, GD Chen, S Manohar - Hearing research, 2022 - Elsevier
Hyperacusis is a debilitating loudness intolerance disorder that can evoke annoyance, fear
and aural facial pain. Although the auditory system seems to be the “central” player …

[HTML][HTML] Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy

H Guest, KJ Munro, G Prendergast, S Howe, CJ Plack - Hearing research, 2017 - Elsevier
In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

Decreased speech-in-noise understanding in young adults with tinnitus

A Gilles, W Schlee, S Rabau, K Wouters… - Frontiers in …, 2016 - frontiersin.org
Objectives: Young people are often exposed to high music levels which make them more at
risk to develop noise-induced symptoms such as hearing loss, hyperacusis, and tinnitus of …

Tinnitus and auditory perception after a history of noise exposure: Relationship to auditory brainstem response measures

NF Bramhall, D Konrad-Martin, GP McMillan - Ear and hearing, 2018 - journals.lww.com
Objectives: To determine whether auditory brainstem response (ABR) wave I amplitude is
associated with measures of auditory perception in young people with normal distortion …

Enhanced central neural gain compensates acoustic trauma-induced cochlear impairment, but unlikely correlates with tinnitus and hyperacusis

D Möhrle, B Hofmeier, M Amend, S Wolpert, K Ni… - Neuroscience, 2019 - Elsevier
For successful future therapeutic strategies for tinnitus and hyperacusis, a subcategorization
of both conditions on the basis of differentiated neural correlates would be of invaluable …

Counseling protocol for a transitional intervention for debilitating hyperacusis

D Cherri, C Formby, CA Secor, DA Eddins - Journal of Speech, Language …, 2024 - ASHA
Introduction: This clinical focus article describes a structured counseling protocol for use with
protected sound management and therapeutic sound in a transitional intervention for …

Background and rationale for a transitional intervention for debilitating hyperacusis

C Formby, CA Secor, D Cherri, DA Eddins - Journal of Speech, Language …, 2024 - ASHA
Purpose: This report provides the experimental, clinical, theoretical, and historical
background that motivated a patented transitional intervention and its implementation and …

A review of auditory gain, low-level noise and sound therapy for tinnitus and hyperacusis

A Sheppard, C Stocking, M Ralli… - International journal of …, 2020 - Taylor & Francis
Abstract Objective: This article reviews:(1) the evidence related to enhanced central gain as
a potential mechanism for the generation of tinnitus and hyperacusis,(2) the neuroplastic …

Neural mechanisms of tinnitus and hyperacusis in acute drug-induced ototoxicity

R Salvi, K Radziwon, S Manohar, B Auerbach… - American journal of …, 2021 - ASHA
Purpose Tinnitus and hyperacusis are debilitating conditions often associated with age-,
noise-, and drug-induced hearing loss. Because of their subjective nature, the neural …