A Bayesian computational model reveals a failure to adapt interoceptive precision estimates across depression, anxiety, eating, and substance use disorders

R Smith, R Kuplicki, J Feinstein… - PLoS computational …, 2020 - journals.plos.org
Recent neurocomputational theories have hypothesized that abnormalities in prior beliefs
and/or the precision-weighting of afferent interoceptive signals may facilitate the …

[HTML][HTML] Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

R Smith, N Kirlic, JL Stewart, J Touthang… - Journal of Psychiatry and …, 2021 - jpn.ca
Background Imbalances in approach-avoidance conflict (AAC) decision-making (eg,
sacrificing rewards to avoid negative outcomes) are considered central to multiple …

Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders

R Smith, JS Feinstein, R Kuplicki, KL Forthman… - Scientific reports, 2021 - nature.com
This study employed a series of heartbeat perception tasks to assess the hypothesis that
cardiac interoceptive processing in individuals with depression/anxiety (N= 221), and …

Diminished responses to bodily threat and blunted interoception in suicide attempters

DC DeVille, R Kuplicki, JL Stewart, MP Paulus… - Elife, 2020 - elifesciences.org
Psychological theories of suicide suggest that certain traits may reduce aversion to physical
threat and increase the probability of transitioning from suicidal ideation to action. Here, we …

Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample

R Smith, N Kirlic, JL Stewart, J Touthang, R Kuplicki… - Scientific reports, 2021 - nature.com
Maladaptive behavior during approach-avoidance conflict (AAC) is common to multiple
psychiatric disorders. Using computational modeling, we previously reported that individuals …

Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach–avoidance conflict: a replication …

R Smith, CA Lavalley, S Taylor, JL Stewart… - Journal of Psychiatry and …, 2023 - jpn.ca
Background: Decision-making under approach–avoidance conflict (AAC; eg, sacrificing
quality of life to avoid feared outcomes) may be affected in multiple psychiatric disorders …

Heightened affective response to perturbation of respiratory but not pain signals in eating, mood, and anxiety disorders

RC Lapidus, M Puhl, R Kuplicki, JL Stewart… - PLoS …, 2020 - journals.plos.org
Several studies have recently suggested that an abnormal processing of respiratory
interoceptive and nociceptive (painful) stimuli may contribute to eating disorder (ED) …

The current clinical approach to feeding and eating disorders aimed to increase personalization of management

UH Schmidt, A Claudino, F Fernández‐Aranda… - World …, 2025 - Wiley Online Library
Feeding and eating disorders (FEDs) are a heterogeneous grouping of disorders at the mind‐
body interface, with typical onset from childhood into emerging adulthood. They occur along …

Neural processes of inhibitory control in American Indian peoples are associated with reduced mental health problems

EJ White, MJ Demuth, M Nacke, N Kirlic… - Social Cognitive and …, 2023 - academic.oup.com
American Indians (AI) experience disproportionately high prevalence of suicide and
substance use disorders (SUD). However, accounting for risk burden (eg historical trauma …

[HTML][HTML] Latent variables for region of interest activation during the monetary incentive delay task

EJ White, R Kuplicki, JL Stewart, N Kirlic, HW Yeh… - Neuroimage, 2021 - Elsevier
Abstract Background The Monetary Incentive Delay task (MID) has been used extensively to
probe anticipatory reward processes. However, individual differences evident during this …