The family Geobacteraceae, with its only valid genus Geobacter, comprises
deltaproteobacteria ubiquitous in soil, sediments, and subsurface environments where metal …

Riboswitches are common gene regulatory units mostly found in bacteria that are capable of
altering gene expression in response to a small molecule. These structured RNA elements …

Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by
acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses …

The oral cavity comprises an environment full of microorganisms. Dysregulation of this
microbial‐cellular microenvironment will lead to a series of oral diseases, such as implant …

Sensing and responding to environmental changes is essential for bacteria to adapt and
thrive, and nucleotide-derived second messengers are central signaling systems in this …

Innate immunity is the first line of host defense against invading pathogens. The detection of
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …

Cellular levels of the second messenger cyclic di-guanosine monophosphate (c-di-GMP)
are determined by the antagonistic activities of diguanylate cyclases and specific …

Since the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs)
have emerged as widely used signaling molecules in most kingdoms of life. The family of …

An RNA-based fluorogenic module consists of a light-up RNA aptamer able to specifically
interact with a fluorogen to form a fluorescent complex. Over the past decade, significant …

The possibility of an RNA World is based on the notion that life on Earth passed through a
primitive phase without proteins, a time when all genomes and enzymes were composed of …