Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also referred to
as drug-induced hypersensitivity syndrome, is a distinct, potentially life-threatening adverse …

Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …

The variant allele HLA‐B* 15: 02 is strongly associated with greater risk of Stevens–Johnson
syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with …

Immune reactions to small molecular compounds, such as drugs, can cause a variety of
diseases involving the skin, liver, kidney, and lungs. In many drug hypersensitivity reactions …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Diagnosis of drug hypersensitivity is difficult, as an enormous amount of different drugs can
elicit various immune‐mediated diseases with distinct pathomechanism. The lymphocyte …

In drug hypersensitivity, drug provocation testing (DPT), also called drug challenge, is the
gold standard for investigation. In recent years, risk stratification has become an important …

Drug rash with eosinophilia and systemic symptoms syndrome is a severe idiosyncratic drug
reaction with a long latency period. It has been described using many terms; however, drug …

The anticonvulsant carbamazepine (CBZ) frequently causes cutaneous adverse drug
reactions (cADRs), including maculopapular eruption (MPE), hypersensitivity syndrome …

The clinical manifestations of drug eruptions can range from mild maculopapular exanthema
to severe cutaneous adverse drug reactions (SCAR), including drug‐induced …