Abstract Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression,
treatment, and complications. A data driven cluster analysis in European individuals with …

Recent studies reveal that bile acid metabolite composition and its metabolism are changed
in metabolic disorders, such as obesity, type 2 diabetes and metabolic associated fatty liver …

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of
transition from normal to a prediabetes state are unidentified. We studied the basal …

Background: Plasma elevated levels of branched chain amino acids (BCAA) and aromatic
amino acids (AAA) have been associated with obesity and insulin resistance, but their …

Objective Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the
underlying physiological response is still not fully understood, though physiological changes …

Objective Severe hypoglycemia is associated with increased cardiovascular death risk, and
platelet responses to hypoglycemia (hypo) have been described. However, the impact of …

Diabetic autonomic peripheral neuropathy (PN) involves a broad spectrum of organs. One of
them is the gastrointestinal (GI) tract. The molecular mechanisms underlying the …

Introduction Hypoglycemia is a major limiting factor in achieving recommended glycemic
targets for people with type 1 diabetes. Exposure to recurrent hypoglycemia results in …

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat
shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia …

Hypoglycemia, as a complication of type 2 diabetes (T2D), causes increased morbidity and
mortality but the physiological response underlying hypoglycemia has not been fully …