A comprehensive overview of Artemisinin and its derivatives as anticancer agents

Z Zeng, D Chen, L Chen, B He, Y Li - European Journal of Medicinal …, 2023 - Elsevier
Artemisinin is the crucial ingredient of artemisia annua, a traditional Chinese medicine used
for the therapy of malaria in China for hundreds of years. In recent years, the anticancer …

Artemisinin and its derivatives: A promising cancer therapy

BH Kiani, WK Kayani, AU Khayam, E Dilshad… - Molecular Biology …, 2020 - Springer
The world is experiencing a cancer epidemic and an increase in the prevalence of the
disease. Cancer remains a major killer, accounting for more than half a million deaths …

[HTML][HTML] Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

D Dolivo, P Weathers, T Dominko - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Fibrosis is a pathological reparative process that can occur in most organs and is
responsible for nearly half of deaths in the developed world. Despite considerable research …

Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin

ND Yang, SH Tan, S Ng, Y Shi, J Zhou… - Journal of Biological …, 2014 - ASBMB
Artesunate (ART) is an anti-malaria drug that has been shown to exhibit anti-tumor activity,
and functional lysosomes are reported to be required for ART-induced cancer cell death …

Ferrostatin‐1‐loaded liposome for treatment of corneal alkali burn via targeting ferroptosis

K Wang, L Jiang, Y Zhong, Y Zhang… - Bioengineering & …, 2022 - Wiley Online Library
Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn‐
induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including …

[HTML][HTML] CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline …

RE Kast, G Karpel-Massler, ME Halatsch - Oncotarget, 2014 - ncbi.nlm.nih.gov
CUSP9 treatment protocol for recurrent glioblastoma was published one year ago. We now
present a slight modification, designated CUSP9*. CUSP9* drugs-aprepitant, artesunate …

Artemisinin and its derivatives as a repurposing anticancer agent: what else do we need to do?

Z Li, Q Li, J Wu, M Wang, J Yu - Molecules, 2016 - mdpi.com
Preclinical investigation and clinical experience have provided evidence on the potential
anticancer effect of artemisinin and its derivatives (ARTs) in the recent two decades. The …

[HTML][HTML] Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis

D Gong, N Wu, H Chen, W Zhang, C Yan, C Zhang… - Redox Biology, 2024 - Elsevier
As the important barrier of intraocular tissue, cornea is easy to suffer various kinds of
injuries. Among them, acute alkali burn is a thorny ophthalmic emergency event, which can …

Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS‑dependent p38 MAPK and protects against cerebral ischemia‑reperfusion …

H Lu, B Wang, N Cui, Y Zhang - Molecular medicine …, 2018 - spandidos-publications.com
Artesunate is a semi-synthetic derivative of artemisinin that is used in the treatment of
patients with malaria. Artesunate has also been reported to exert immune‑regulatory …

[HTML][HTML] Intracellular catalase activity instead of glutathione level dominates the resistance of cells to reactive oxygen species

MX Zhao, JL Wen, L Wang, XP Wang… - Cell Stress and …, 2019 - Elsevier
Artesunate (ARS) induced significant reactive oxygen species (ROS) generation in HepG2,
HeLa, and A549 lines. However, ARS induced ROS-dependent apoptosis in HeLa and …