Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

Identifying essential genes in a given organism is important for research on their
fundamental roles in organism survival. Furthermore, if possible, uncovering the links …

Programmable control of spatial genome organization is a powerful approach for studying
how nuclear structure affects gene regulation and cellular function. Here, we develop a …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

RNA–protein interactions underlie a wide range of cellular processes. Improved methods
are needed to systematically map RNA–protein interactions in living cells in an unbiased …

Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in
tissue progenitor cells and cancer cells. Active human telomerase consists of at least three …

Telomerase is the ribonucleoprotein enzyme that catalyzes the extension of telomeric DNA
in eukaryotes. Recent work has begun to reveal key aspects of the assembly of the human …