A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis
S Ghorbani, VW Yong - Brain, 2021 - academic.oup.com
Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …
Targeting pyrimidine metabolism in the era of precision cancer medicine
W Wang, J Cui, H Ma, W Lu, J Huang - Frontiers in oncology, 2021 - frontiersin.org
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …
Oxidative stress and metabolic perturbations in wooden breast disorder in chickens
B Abasht, MF Mutryn, RD Michalek, WR Lee - PloS one, 2016 - journals.plos.org
This study was conducted to characterize metabolic features of the breast muscle (pectoralis
major) in chickens affected with the Wooden Breast myopathy. Live birds from two purebred …
major) in chickens affected with the Wooden Breast myopathy. Live birds from two purebred …
Hyaluronan: biosynthesis and signaling
Background Hyaluronan is a critical component of extracellular matrix with several different
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …
roles. Besides the contribution to the tissue hydration, mechanical properties and correct …
4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer
Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …
chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous …
Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review
X Zheng, B Wang, X Tang, B Mao, Q Zhang… - Carbohydrate …, 2023 - Elsevier
Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …
in tissues gradually decreases with age, causing age-related health problems. Exogenous …
Cartilage biology in osteoarthritis—lessons from developmental biology
AA Pitsillides, F Beier - Nature Reviews Rheumatology, 2011 - nature.com
The cellular and molecular mechanisms responsible for the initiation and progression of
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …
osteoarthritis (OA), and in particular cartilage degeneration in OA, are not completely …
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
A Kultti, S Pasonen-Seppänen, M Jauhiainen… - Experimental cell …, 2009 - Elsevier
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …