As evidence has mounted that virus-infected cells, such as cancer cells, negatively regulate
the function of T-cells via immune checkpoints, it has become increasingly clear that viral …

This review focuses on new findings about the inflammatory status involved in the
development of human liver cirrhosis induced by the two main causes, hepatitis C virus …

Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-
translational modifications (PTMs) have been extensively studied in malignancies due to its …

The global prevalence of liver cancer is rapidly rising, mostly as a result of the amplified
incidence rates of viral hepatitis, alcohol abuse and obesity in recent decades. Treatment …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) are increased in patients with
chronic hepatitis C, which may contribute to the sustained suppression of hepatitis C virus …

Cytokines and chemokines play an important role in defense against viral infection and
modulating immune response. However, expression prolife of serum cytokines and …

Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world, with a high
relapse rate. Delayed symptom onset observed in 70–80% of patients leads to diagnosis in …

Hepatitis C viral infection persists and becomes chronic in a majority of affected individuals.
Numerous factors have been described to explain how the virus manages to escape the …

Despite their differential cell tropisms, HIV-1 and HCV dramatically influence disease
progression in coinfected patients. Macrophages are important target cells of HIV-1. We …

The immunological result of infection with Hepatitis C virus (HCV) depends on the delicate
balance between a vigorous immune response that may clear the infection, but with a risk of …