In this review, we describe a detailed investigation about the structural variations and
relative activity of 1, 8-naphthalimide based intercalators and anticancer agents. The 1, 8 …

Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Cancer is one of the most prevailing disease conditions, which occurs due to uncontrolled
cell division either due to natural mutation to the genes or due to changes induced by …

Combinatorial inhibition of Topoisomerase 1 (TOP1) and Poly (ADP-ribose) polymerase 1
(PARP1) is an attractive therapeutic strategy which is under active investigation to address …

Abstract A series of phenanthro [9, 10-d] imidazole/oxazole and acenaphtho [1, 2-d]
imidazole with different aryl groups at C2-position has been synthesized. These compounds …

A series of novel methyl 4-(4-amidoaryl)-3-methoxythiophene-2-carboxylate derivatives
were designed against the active site of protein tyrosine phosphatise 1B (PTP1B) enzyme …

A series of novel naphthalimide-derived metronidazoles as new type of antimicrobial agents
were for the first time designed, synthesized and characterized by NMR, IR and HRMS …

Cancer still remains a continued threat for human race in the 21st century. It is the major
cause of human casualties globally and is thus, a hot topic of research in medicinal …

Elinafide is a bis-intercalating naphthalimide, but due to serious side effects, it has failed in
clinical trials phase II. In light of this, we have modified the elinifide and synthesized the new …

We have designed and synthesized a novel, water-soluble naphthalimide-histidine receptor
(1) with excellent fluorescent properties. Functioning of the synthesized receptor was …