Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance
between bone resorption and bone formation. The regulation of physiological bone …

Osteocytes are master regulators of the skeleton. We mapped the transcriptome of
osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and …

Osteoporosis caused by aging is characterized by reduced bone mass and accumulated
adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and …

Here, we report inducible mosaic animal for perturbation (iMAP), a transgenic platform
enabling in situ CRISPR targeting of at least 100 genes in parallel throughout the mouse …

The hypothalamus is a brain region that exhibits highly conserved anatomy across
vertebrate species and functions as a central regulatory hub for many physiological …

A library of 31 natural neo-clerodanes isolated from Ajuga decumbens was assayed for
antiosteoporosis. This results in 18 neo-clerodane osteoclastogenesis inhibitors, and …

Bone is a dynamically active tissue whose health status is closely related to its construction
and remodeling, and imbalances in bone homeostasis lead to a wide range of bone …

Introduction. In osteoporosis field, it had been clinically well established a given relationship
between bone formation and lipid accumulation. Although numerous molecules had been …

Haploid embryos have contributed significantly to our understanding of the role of parental
genomes in development and can be applied to important biotechnology for human and …