A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Biomolecules such as antibodies, proteins, and peptides are important tools for chemical
biology and leads for drug development. They have been used to inhibit a variety of …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Despite unequivocal roles in disease, transcription factors (TFs) remain largely untapped as
pharmacologic targets due to the challenges in targeting protein–protein and protein–DNA …

Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …

Native mass spectrometry has emerged as an important tool for gas-phase structural
biology. However, the conformations that a biomolecular ion adopts in the gas phase can …

Biomacromolecules have long been at the leading edge of academic and pharmaceutical
drug development and clinical translation. With the clinical advances of new therapeutics …

Simple Summary The small GTPase RAB11 is a master regulator of both vesicular trafficking
and membrane dynamic defining the surface proteome of cellular membranes. As a …

Stapled peptides with significantly enhanced pharmacological profiles have emerged as
promising therapeutic molecules due to their remarkable resistance to proteolysis and …