RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

Shortening and removal of the 3′ poly (A) tail of mature mRNA by poly (A)-specific 3′
exonucleases (deadenylases) is the initial and often rate-limiting step in mRNA degradation …

Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this …

Translation and decay of eukaryotic mRNAs is controlled by shortening of the poly (A) tail
and release of the poly (A)-binding protein Pab1/PABP. The Ccr4-Not complex contains two …

RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and
decay. Guanylation of the poly (A) tail was discovered recently, yet the enzymology and …

The Ccr4–Not complex is a unique, essential and conserved multi-subunit complex that acts
at the level of many different cellular functions to regulate gene expression. Two enzymatic …

Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …

Synthetic mRNAs are rising rapidly as alternative therapeutic agents for delivery of proteins.
However, the practical use of synthetic mRNAs has been restricted by their low cellular …

The purpose of this review is to provide an analysis of the latest developments on the
functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating …

Hepatokines, secretory proteins from the liver, mediate inter-organ communication to
maintain a metabolic balance between food intake and energy expenditure. However …