Immunology of Mycobacterium tuberculosis Infections
JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
T cell metabolism in infection
JA Wik, BS Skålhegg - Frontiers in immunology, 2022 - frontiersin.org
T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …
BNT162b vaccines protect rhesus macaques from SARS-CoV-2
AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - Nature, 2021 - nature.com
A safe and effective vaccine against COVID-19 is urgently needed in quantities that are
sufficient to immunize large populations. Here we report the preclinical development of two …
sufficient to immunize large populations. Here we report the preclinical development of two …
The immunoregulatory landscape of human tuberculosis granulomas
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …
infected tissues, the architecture and composition of which are thought to affect disease …
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …
The immune landscape in tuberculosis reveals populations linked to disease and latency
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …
approximately one-fourth of the world's population. The immune mechanisms that govern …
The tuberculous granuloma and preexisting immunity
Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …
A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates
AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - BioRxiv, 2020 - biorxiv.org
To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …
Role of indoleamine 2, 3-dioxygenase in health and disease
IDO1 (indoleamine 2, 3-dioxygenase 1) is a member of a unique class of mammalian haem
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …
dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino …
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
US Gautam, TW Foreman, AN Bucsan… - Proceedings of the …, 2018 - National Acad Sciences
Mycobacterium tuberculosis continues to cause devastating levels of mortality due to
tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the …
tuberculosis (TB). The failure to control TB stems from an incomplete understanding of the …