Protein interactions define the homeostatic state of the cell. Our ability to understand these
interactions and their role in both health and disease is tied to our knowledge of the 3D …

Protein–protein binding is one of the critical events in biology, and knowledge of proteic
complexes three‐dimensional structures is of fundamental importance for the biochemical …

Glioblastoma (GBM), the most common and lethal primary brain tumor, with a median
survival rate of only 15 months, remains incurable despite intensive multimodal treatment of …

Influenza virus remains a serious health threat, owing to its ability to evade immune
surveillance through rapid genetic drift and reassortment. Here we used a human non …

Understanding the natural evolution and structural changes involved in broadly neutralizing
antibody (bnAb) development holds great promise for improving the design of prophylactic …

The high substrate selectivity of the ubiquitin/proteasome system is mediated by a large
group of E3 ubiquitin ligases. The ubiquitin ligase CHIP regulates the degradation of …

Protein arginine methyltransferase 5 (PRMT5) is a master epigenetic regulator and an
extensively validated therapeutic target in multiple cancers. Notably, PRMT5 is the only …

Recent studies have demonstrated the presence of estrogen receptor (ER) β in the
mitochondria in various cell types and tissues, but the exact function of this localization …

Protein-protein interactions (PPIs) have a pivotal role in many biological processes
suggesting that targeting macromolecular complexes will open new avenues for the design …

Many eukaryotic regulatory proteins adopt distinct bound and unbound conformations, and
use this structural flexibility to bind specifically to multiple partners. However, we lack an …