Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The epithelial Na+ channel (ENaC) is a pathway for Na+ transport across epithelia,
including the kidney collecting duct, lung, and distal colon. ENaC is critical for Na+ …

Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid
clearance at birth and lung edema clearance in adulthood. In this study, we tested whether …

The epithelial Na+ channel (ENaC) is a tetramer of two α-, one β-, and one γ-subunit, but
little is known about its assembly and processing. Because co-expression of mouse ENaC …

Stretch-and swelling-activated cation (SSAC) channels play essential roles not only in
sensing and transducing external mechanical stresses but also in regulating cell volume in …

Abstract The epithelial Na+ channel (ENaC) forms the pathway for Na+ absorption in the
kidney collecting duct and other epithelia. Dominant gain-of-function mutations cause …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

The systemic actions of aldosterone are well documented; however, in comparison, our
understanding of the cellular and molecular mechanisms by which aldosterone orchestrates …

We carried out semiquantitative immunoblotting of kidney to identify apical sodium
transporter proteins whose abundances are regulated by angiotensin II. In NaCl-restricted …

Acute hormonal regulation of the epithelial sodium channel (ENaC) in tight epithelia
increases transcellular Na+ transport via trafficking of intracellular channels to the apical …