[HTML][HTML] Human immunodeficiency virus-1 induces and targets host genomic R-loops for viral genome integration
K Park, D Lee, J Jeong, S Lee, S Kim, K Ahn - eLife, 2024 - elifesciences.org
Although HIV-1 integration sites are considered to favor active transcription units in the
human genome, high-resolution analysis of individual HIV-1 integration sites have shown …
human genome, high-resolution analysis of individual HIV-1 integration sites have shown …
Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors
M Pávová, PE Reyes-Gutiérrez, J Kozák, J Dobiaš… - Scientific Reports, 2023 - nature.com
The secondary structure of nucleic acids containing quartets of guanines, termed G-
quadruplexes, is known to regulate the transcription of many genes. Several G …
quadruplexes, is known to regulate the transcription of many genes. Several G …
Specialized DNA structures act as genomic beacons for integration by evolutionarily diverse retroviruses
HP Kohio, HO Ajoge, MD Coleman, E Ndashimye… - Viruses, 2023 - mdpi.com
Retroviral integration site targeting is not random and plays a critical role in expression and
long-term survival of the integrated provirus. To better understand the genomic environment …
long-term survival of the integrated provirus. To better understand the genomic environment …
Unlocking the power of G-quadruplex for anti-HIV1 development
K Ooi, Y Qi - MEDS Clinical Medicine, 2023 - clausiuspress.com
The role of G-quadruplexes (GQP) in the life cycle of other viruses has led to the speculation
that they may also have a function in the HIV genome. This paper aims to write-up on the …
that they may also have a function in the HIV genome. This paper aims to write-up on the …