African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa

E Kamau, S Campino, L Amenga-Etego… - The Journal of …, 2015 - academic.oup.com
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to
be important determinants of artemisinin resistance in Southeast Asia. This study …

[HTML][HTML] An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

A Ahouidi, M Ali, J Almagro-Garcia… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

A Amambua-Ngwa, L Amenga-Etego, E Kamau… - Science, 2019 - science.org
Understanding genomic variation and population structure of Plasmodium falciparum across
Africa is necessary to sustain progress toward malaria elimination. Genome clustering of …

A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment

F Huang, S Takala-Harrison, CG Jacob… - The Journal of …, 2015 - academic.oup.com
Abstract Background. Artemisinin resistance in Plasmodium falciparum has emerged in
Southeast Asia and poses a threat to malaria control and elimination. Mutations in a P …

Genetic diversity and drug resistance surveillance of Plasmodium falciparum for malaria elimination: is there an ideal tool for resource-limited sub-Saharan Africa?

TO Apinjoh, A Ouattara, VPK Titanji, A Djimde… - Malaria journal, 2019 - Springer
The intensification of malaria control interventions has resulted in its global decline, but it
remains a significant public health burden especially in sub-Saharan Africa (sSA) …

An inventory of supranational antimicrobial resistance surveillance networks involving low-and middle-income countries since 2000

EA Ashley, J Recht, A Chua, D Dance… - Journal of …, 2018 - academic.oup.com
Low-and middle-income countries (LMICs) shoulder the bulk of the global burden of
infectious diseases and drug resistance. We searched for supranational networks …

Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies

W Tavares, J Morais, JF Martins, RJ Scalsky… - Malaria Journal, 2022 - Springer
Over the past two decades, a considerable expansion of malaria interventions has occurred
at the national level in Angola, together with cross-border initiatives and regional efforts in …

Population genomics of Plasmodium ovale species in sub-Saharan Africa

K Carey-Ewend, ZR Popkin-Hall, A Simkin… - Nature …, 2024 - nature.com
Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria
parasites endemic to Africa and Asia that were previously thought to represent a single …