Paracetamol use during pregnancy—a call for precautionary action

AZ Bauer, SH Swan, D Kriebel, Z Liew… - Nature Reviews …, 2021 - nature.com
Abstract Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as
acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to …

Using experimental models to decipher the effects of acetaminophen and NSAIDs on reproductive development and health

B Boizet-Bonhoure, S Déjardin, M Rossitto… - Frontiers in …, 2022 - frontiersin.org
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid),
diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or …

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

KK Sznajder, DM Teti, KH Kjerulff - PLoS One, 2022 - journals.plos.org
Background Acetaminophen is one of the most commonly used drugs during pregnancy
globally. Recent studies have reported associations between prenatal exposure to …

[HTML][HTML] Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1hi neutrophil in myocardial ischemia–reperfusion injury

Y Dong, Z Kang, Z Zhang, Y Zhang, H Zhou, Y Liu… - Science Bulletin, 2024 - Elsevier
Myocardial ischemia–reperfusion injury (MIRI) is a major hindrance to the success of cardiac
reperfusion therapy. Although increased neutrophil infiltration is a hallmark of MIRI, the …

Prenatal exposure to acetaminophen at different doses, courses and time causes testicular dysplasia in offspring mice and its mechanism

Y Liu, S Chen, Z Kong, Y Guo, H Wang - Chemosphere, 2023 - Elsevier
Epidemiological investigation suggested that the use of acetaminophen during pregnancy
may cause offspring testicular dysplasia, but no systematic study has been conducted. In this …

Acetaminophen overdose inhibits steroidogenic acute regulatory protein expression by reducing AKT-mediated SP1 expression in human granulosa-lutein cells

JC Cheng, Q Zhang, L Zhang, B Bi, H Wang… - Reproductive …, 2025 - Elsevier
Overdose of acetaminophen (APAP) has been shown to adversely affect the outcome of
pregnancy. The steroidogenic acute regulatory protein (StAR) plays a pivotal role in …

Maternal administration of APAP induces angiogenesis disorders in mouse placenta via SOCS3/JAK1/STAT3 pathway

Y Dai, J He, X Chen, Y Geng, Z Chen, F Liu, F Li… - Reproductive …, 2024 - Elsevier
Acetaminophen (APAP, also known as paracetamol) is a commonly used antipyretic and
analgesic that is considered safe to use during pregnancy. However, a growing body of …

In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder

T Furnary, R Garcia-Milian, Z Liew, S Whirledge… - Toxics, 2021 - mdpi.com
Recent epidemiological studies suggest that prenatal exposure to acetaminophen (APAP) is
associated with increased risk of Autism Spectrum Disorder (ASD), a neurodevelopmental …

Effects of a Therapeutic Dose and a High-Dose of Acetaminophen on Blood-Brain Barrier Tight Junction Proteins and Efflux Transporters

J Yang - 2023 - search.proquest.com
Acetaminophen (APAP) is one of the most consumed over-the-counter and prescription
medications worldwide due to its effective analgesic and antipyretic properties. Given its …

Poluentes emergentes: contexto legal e impactos ambientais da farmacocontaminação

ACP Araújo - 2021 - bdtd.ibict.br
A ocorrência de produtos farmacêuticos e seus produtos de transformação no meio
ambiente é comprovada por diversos estudos realizados ao longo dos últimos anos em …