The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …

Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise
molecular mechanisms underlying its pathogenicity remain unclear. It has recently been …

Background and Purpose—Adenosine in many types of RNAs can be converted to m6A (N6-
methyladenosine) which is a highly dynamic epitranscriptomic modification that regulates …

Background and Purpose—Circular RNAs (circRNAs) are a novel class of noncoding RNAs
formed from many protein-coding genes by backsplicing. Although their physiological …

Background The prognosis of spinal cord injury (SCI) is closely related to secondary injury,
which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Transient focal ischemia decreased microRNA-7 (miR-7) levels, leading to derepression of
its major target α-synuclein (α-Syn) that promotes secondary brain damage. Circular RNA …

The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the
typical motor symptoms of Parkinson's disease (PD). Lewy bodies (LB) and Lewy neurites …