Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

Fibrogenesis is a progressive scarring event resulting from disrupted regular wound healing
due to repeated tissue injury and can end in organ failure, like in liver cirrhosis. The …

The liver has a unique ability to regenerate,; however, in the setting of acute liver failure
(ALF), this regenerative capacity is often overwhelmed, leaving emergency liver …

The liver possesses a unique regenerative ability to restore its original mass, in this regard,
partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly …

The liver is the largest organ of the mammalian body and has the remarkable ability to fully
regenerate in order to maintain tissue homeostasis. The adult liver consists of hexagonal …

Constructing an engineered hepatic lobule-mimetic model is challenging owing to
complicated lobular architecture and crucial hepatic functionality. Our previous study has …

Integrins are heterodimeric transmembrane proteins that play important roles in various
biological processes. Most integrins serve as adhesion molecules and transmit bidirectional …

Significance: Systemic autoimmunity affects 3%–5% of the population worldwide. Systemic
lupus erythematosus (SLE) is a prototypical form of such condition, which affects 20–150 of …

The liver is the largest internal organ and gland of our body. Centrally placed, it receives
blood from most of the intestine, the pancreas, and the spleen. The venous blood enters the …

Many integrins transmit signals through global conformational changes. However, it is
unclear whether integrin αvβ8 adopts a similar mechanism during integrin activation and …