The role of lipopolysaccharide-induced cell signalling in chronic inflammation

MJ Page, DB Kell, E Pretorius - Chronic Stress, 2022 - journals.sagepub.com
Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

Outer membrane lipid secretion and the innate immune response to gram-negative bacteria

NP Giordano, MB Cian, ZD Dalebroux - Infection and immunity, 2020 - Am Soc Microbiol
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that
consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The …

[HTML][HTML] Molecular structures of fluid phase phosphatidylglycerol bilayers as determined by small angle neutron and X-ray scattering

J Pan, FA Heberle, S Tristram-Nagle… - … et Biophysica Acta (BBA …, 2012 - Elsevier
We have determined the molecular structures of commonly used phosphatidylglycerols
(PGs) in the commonly accepted biologically relevant fluid phase. This was done by …

Structural biology of the LPS recognition

R Jerala - International Journal of Medical Microbiology, 2007 - Elsevier
Bacterial endotoxin (lipopolysaccharide–LPS) as one of the most potent inducers of the
immune system is recognized by a complex cascade of extracellular “pattern recognition …

Surfactant lipids at the host–environment interface. Metabolic sensors, suppressors, and effectors of inflammatory lung disease

MB Fessler, RS Summer - American Journal of Respiratory Cell and …, 2016 - atsjournals.org
The lipid composition of pulmonary surfactant is unlike that of any other body fluid. This
extracellular lipid reservoir is also uniquely susceptible by virtue of its direct and continuous …

Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus–induced inflammation and infection

M Numata, HW Chu, A Dakhama… - Proceedings of the …, 2010 - National Acad Sciences
Respiratory syncytial virus (RSV) is the most common cause of hospitalization for respiratory
tract infection in young children. It is also a significant cause of morbidity and mortality in …

[HTML][HTML] The role of lipopolysaccharide-binding protein in modulating the innate immune response

J Zweigner, RR Schumann, JR Weber - Microbes and Infection, 2006 - Elsevier
Lipopolysaccharide-binding protein (LBP) has a well-established role in Gram-negative
infection. New data suggest a more expanded role for LBP as a general recognition …

Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

RR Schumann - Biochemical Society Transactions, 2011 - portlandpress.com
LBP [LPS (lipopolysaccharide)-binding protein] was discovered approximately 25 years ago.
Since then, substantial progress has been made towards our understanding of its function in …

Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics

S Wang, K Tang, Y Lu, Z Tian, Z Huang, M Wang… - Clinica chimica acta, 2021 - Elsevier
Lipid mediators play an essential role in the pathogenesis of asthma. Many studies on the
differential expression of sphingolipids and fatty acid exist, but relatively few concerned …

[HTML][HTML] Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids

M Numata, DR Voelker - Biochimica et Biophysica Acta (BBA)-Molecular …, 2022 - Elsevier
Pulmonary surfactant is a mixture of lipids and proteins, consisting of 90% phospholipid, and
10% protein by weight, found predominantly in pulmonary alveoli of vertebrate lungs. Two …