Recent advances in age-related macular degeneration therapies

M Fabre, L Mateo, D Lamaa, S Baillif, G Pagès… - Molecules, 2022 - mdpi.com
Age-related macular degeneration (AMD) was described for the first time in the 1840s and is
currently the leading cause of blindness for patients over 65 years in Western Countries …

Experimental models in neovascular age related macular degeneration

O Rastoin, G Pagès, M Dufies - International journal of molecular sciences, 2020 - mdpi.com
Neovascular age-related macular degeneration (vAMD), characterized by the neo-
vascularization of the retro-foveolar choroid, leads to blindness within few years. This …

[HTML][HTML] Different Therapeutic Approaches for Dry and Wet AMD

N Marchesi, M Capierri, A Pascale… - International Journal of …, 2024 - mdpi.com
Age-related macular degeneration (AMD) is the most common cause of irreversible loss of
central vision in elderly subjects, affecting men and women equally. It is a degenerative …

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

J Liu, L Huang, M Wan, G Chen, M Su… - Environmental …, 2022 - Wiley Online Library
Due to an increasing number of abused drugs dumped into the wastewater, more and more
drugs are detected in the water environment, which may affect the survival of aquatic …

Comparison of cardiotoxicity induced by alectinib, apatinib, lenvatinib and anlotinib in zebrafish embryos

J Liu, W Li, S Sun, L Huang, M Wan, X Li… - … and Physiology Part C …, 2024 - Elsevier
Four tyrosine kinase inhibitors, alectinib, apatinib, lenvatinib and anlotinib, have been
shown to be effective in the treatment of clinical tumors, but their cardiac risks have also …

Patient preferences in retinal drug delivery

B Jacobs, N Palmer, T Shetty, H Dimaras… - Scientific Reports, 2021 - nature.com
Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs,
with relatively low patient compliance and potential risks. Ongoing research explores …

[HTML][HTML] Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL …

Y Yao, Z Liu, M Zhao, Z Chen, P Li, Y Zhang… - … Pharmaceutica Sinica B, 2020 - Elsevier
Angiokinases, such as vascular endothelial-, fibroblast-and platelet-derived growth factor
receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti …

Brivanib, a multitargeted small‐molecule tyrosine kinase inhibitor, suppresses laser‐induced CNV in a mouse model of neovascular AMD

L Li, M Zhu, W Wu, B Qin, J Gu, Y Tu… - Journal of Cellular …, 2020 - Wiley Online Library
In age‐related macular degeneration (AMD), choroidal neovascularization (CNV), a major
pathologic feature of neovascular AMD (nAMD), affects 10% of patients, potentially causing …

Mitochondrial dynamics imbalance and mitochondrial dysfunction contribute to the molecular cardiotoxic effects of lenvatinib

AG Akyildiz, T Boran, AT Jannuzzi… - Toxicology and applied …, 2021 - Elsevier
Lenvatinib is a tyrosine kinase inhibitor (TKI) approved for the treatment of resistant
differentiated thyroid cancer, advanced renal cell carcinoma, unresectable hepatocellular …

Photosensitizer formulations in photodynamic therapy of age-related macular degeneration

S Beirão, PMR Pereira, R Fernandes… - European Journal of …, 2024 - Elsevier
Age-related macular degeneration (AMD) is a progressive degenerative disease that leads
to visual impairment, predominantly affecting the elderly. Despite significant advancements …