Irinotecan (CPT11) and its active metabolite ethyl-10-hydroxy-camptothecin (SN38) are
broad-spectrum cytotoxic anticancer agents. Both cause cell death in rapidly dividing cells …

Tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. While the
safety of THC and cannabis has been extrapolated from millennia of recreational use …

The use of traditional Chinese medicine (TCM) has obtained more and more acceptance all
over the world due to its multi-target and multi-level function characteristics. Clopidogrel is a …

Abstract Carboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in
the activation or deactivation of many therapeutic agents, thus affecting their …

Background: Some pediatric patients with attention-deficit/hyperactivity disorder (ADHD) use
natural health products (NHPs) such as herbal remedies. Although herbal remedies are …

Dabigatran etexilate (DABE), an oral anticoagulant prodrug, is nearly completely
metabolized to the dabigatran (DAB) active metabolite by carboxylesterase-1 (CES1) and …

As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific
plausibility of nutraceutical and botanical interventions for prevention and treatment is …

ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …

Abstract Kratom,(Mitragyna Speciosa Korth.) is a plant indigenous to Southeast Asia whose
leaves are cultivated for a variety of medicinal purposes and mostly consumed as powders …

Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of
particular significance to various indigenous cultures in the South Pacific region …