The tumour microenvironment, also termed the tumour stroma or tumour mesenchyme,
includes fibroblasts, immune cells, blood vessels and the extracellular matrix and …

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various
hormones and extracellular matrix components. FAP is highly upregulated in a wide variety …

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment.
Here, we characterize four CAF subsets in breast cancer with distinct properties and levels …

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer
progression remain to be fully understood. While altered glucose metabolism in CAFs could …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Background Integrated PET/MRI is a promising modality for breast assessment. The most
frequently used tracer, fluorine 18 (18F) fluorodeoxyglucose (FDG), is applied for whole …

Activated fibroblasts are key players in the injury response, tumorigenesis, fibrosis, and
inflammation. Dichotomous outcomes in response to varied stroma-targeted therapies in …

Metastasis is facilitated by cancer-associated fibroblasts (CAF) in the tumor
microenvironment through mechanisms yet to be elucidated. In this study, we used a size …

Progress in understanding tumor stromal biology has been constrained in part because
cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type …

Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …