COVIDomics: The proteomic and metabolomic signatures of COVID-19

M Costanzo, M Caterino, R Fedele, A Cevenini… - International journal of …, 2022 - mdpi.com
Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

[HTML][HTML] Complement activation in COVID-19 and targeted therapeutic options: a scoping review

EHT Lim, RBE van Amstel, VV de Boer, LA van Vught… - Blood Reviews, 2023 - Elsevier
Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …

MetaboliteCOVID: A manually curated database of metabolite markers for COVID-19

L Ren, L Ning, Y Yang, T Yang, X Li, S Tan, P Ge… - Computers in Biology …, 2023 - Elsevier
In the realm of unraveling COVID-19's intricacies, numerous metabolomic investigations
have been conducted to discern the unique metabolic traits exhibited within infected …

Label-free SERS for rapid differentiation of SARS-CoV-2-induced serum metabolic profiles in non-hospitalized adults

M Chisanga, H Williams, D Boudreau… - Analytical …, 2023 - ACS Publications
COVID-19 represents a multi-system infectious disease with broad-spectrum manifestations,
including changes in host metabolic processes connected to the disease pathogenesis …

Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement …

F Ciccosanti, M Antonioli, A Sacchi, S Notari, A Farina… - Clinical proteomics, 2022 - Springer
Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …

Immune cell plasticity in inflammation: Insights into description and regulation of immune cell phenotypes

A Margraf, M Perretti - Cells, 2022 - mdpi.com
Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …

An overview of technologies for MS-based proteomics-centric multi-omics

AT Rajczewski, PD Jagtap, TJ Griffin - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Mass spectrometry-based proteomics reveals dynamic molecular signatures
underlying phenotypes reflecting normal and perturbed conditions in living systems …

Detection of mutant peptides of SARS-CoV-2 variants by LC/MS in the DDA approach using an in-house database

S Rajoria, A Halder, I Tarnekar, P Pal… - Journal of Proteome …, 2023 - ACS Publications
Equipped with a dramatically high mutation rate, which happens to be a signature of RNA
viruses, SARS-CoV-2 trampled across the globe infecting individuals of all ages and …

Application of omics technology to combat the COVID‐19 pandemic

J Yang, Y Yan, W Zhong - MedComm, 2021 - Wiley Online Library
Abstract As of August 27, 2021, the ongoing pandemic of coronavirus disease 2019 (COVID‐
19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has …

Integration of Omics Data and Network Models to Unveil Negative Aspects of SARS-CoV-2, from Pathogenic Mechanisms to Drug Repurposing

L Bernardo, A Lomagno, PL Mauri, D Di Silvestre - Biology, 2023 - mdpi.com
Simple Summary SARS-CoV-2 caused the COVID-19 health emergency, affecting millions
of people worldwide. Samples collected from hospitalized or dead patients from the early …