The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Protein–protein interactions are fundamental to various aspects of cell biology with many
protein complexes participating in numerous fundamental biological processes such as …

Proximity labeling (PL) with genetically-targeted promiscuous enzymes has emerged as a
powerful tool for unbiased proteome discovery. By combining the spatiotemporal specificity …

Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …

Human apolipoprotein E (APOE), originally known for its role in lipid metabolism, is
polymorphic with three major allele forms, namely, APOEε2, APOEε3, and APOEε4, leading …

The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11. 1, which
is a voltage-gated K+ channel protein mainly expressed in heart and brain tissue. HERG …

Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts
in recent decades have established the core protein componentry of these organelles and …

Motivation Recent development of deep-learning methods has led to a breakthrough in the
prediction accuracy of 3D protein structures. Extending these methods to protein pairs is …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early-onset
neurodegenerative disease caused by mutations in the SACS gene, encoding Sacsin. Initial …

Co-fractionation mass spectrometry (CF-MS) uses biochemical fractionation to isolate and
characterize macromolecular complexes from cellular lysates without the need for affinity …