Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Simple Summary Genome duplication and the faithful segregation of chromosomes to
daughter cells are crucial for the maintenance of genome stability. Replication initiators play …

The effect of mutations in the P53 family of transcription factors on their biological functions,
including partial or complete loss of transcriptional activity, has been confirmed several …

Replication timing (RT) is the temporal order in which genomic DNA is replicated during S
phase. Early and late replication correlate with transcriptionally active and inactive …

Replication stress, a major hallmark of cancers, and ensuing genome instability source from
impaired progression of replication forks. The first line of defense against fork slowing is …

The goal of this introduction is not to provide an extensive overview of the literature on the
topics at hand, but rather to introduce ideas and speculations originating from past work and …