Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the
anxiolytic effect of the benzodiazepine class of γ-aminobutyric acid (GABA) receptor …

The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types …

Type A γ-aminobutyric acid (GABAA) receptors are pentameric ligand-gated ion channels
and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system …

Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological
conditions, mainly of genetic origin, characterized by stereotyped behavior, marked …

As key functional units in neural circuits, different types of neuronal synapses play distinct
roles in brain information processing, learning, and memory. Synaptic abnormalities are …

INTRODUCTION During development, brain circuits go through phases of synapse
formation, stabilization, or elimination. γ-aminobutyric acid–mediated (GABAergic) synapse …

Cellular mechanisms that regulate the interplay of synaptic excitation and inhibition are
thought to be central to the functional stability of healthy neuronal circuits. A growing body of …

Inflammation has been implicated in the progression of neurological disease, yet precisely
how inflammation affects neuronal function remains unclear. Tumor necrosis factor-α (TNFα) …

Stiff person syndrome spectrum disorders (SPSD) are a group of rare neuroimmunological
disorders that often include painful spasms and rigidity. However, patients have highly …

GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …