Staphylococcus aureus Nasal Colonization: An Update on Mechanisms, Epidemiology, Risk Factors, and Subsequent Infections

A Sakr, F Brégeon, JL Mège, JM Rolain… - Frontiers in …, 2018 - frontiersin.org
Up to 30% of the human population are asymptomatically and permanently colonized with
nasal Staphylococcus aureus. To successfully colonize human nares, S. aureus needs to …

The staphylococcal biofilm: adhesins, regulation, and host response

AE Paharik, AR Horswill - Virulence mechanisms of bacterial …, 2016 - Wiley Online Library
The Staphylococcus genus includes a diverse group of commensals that colonize mammals
on the skin or mucous membranes. Some of the best‐known members of this genus, such as …

Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria

LA Marraffini, AC DeDent… - … and molecular biology …, 2006 - Am Soc Microbiol
The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

[HTML][HTML] Staphylococcus aureus: determinants of human carriage

JUE Sollid, AS Furberg, AM Hanssen… - Infection, genetics and …, 2014 - Elsevier
Staphylococcus aureus is a common human commensal but carriage varies between eg
geographic location, age, gender, ethnicity and body niche. The nares, throat and perineum …

[HTML][HTML] Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

H Miajlovic, PG Fallon, AD Irvine, TJ Foster - Journal of Allergy and Clinical …, 2010 - Elsevier
BACKGROUND: Colonization of the skin by Staphylococcus aureus in individuals with
atopic dermatitis exacerbates inflammation. Atopic dermatitis is associated with loss-of …

Surface adhesins of Staphylococcus aureus

SR Clarke, SJ Foster - Advances in microbial physiology, 2006 - Elsevier
An important facet in the interaction between Staphylococcus aureus and its host is the
ability of the bacterium to adhere to human extracellular matrix components and serum …

[HTML][HTML] A “dock, lock, and latch” structural model for a staphylococcal adhesin binding to fibrinogen

K Ponnuraj, MG Bowden, S Davis, S Gurusiddappa… - Cell, 2003 - cell.com
Gram-positive pathogens such as staphylococci contain multiple cell wall-anchored proteins
that serve as an interface between the microbe and its environment. Some of these proteins …

Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin

ME Mulcahy, JA Geoghegan, IR Monk… - PLoS …, 2012 - journals.plos.org
Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and
bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus …

Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization

LM O'Brien, EJ Walsh, RC Massey… - Cellular …, 2002 - Wiley Online Library
Staphylococcus aureus is an important cause of sepsis in both community and hospital
settings, a major risk factor for which is nasal carriage of the bacterium. Eradication of …

A 'Collagen Hug' Model for Staphylococcus aureus CNA binding to collagen

Y Zong, Y Xu, X Liang, DR Keene, A Höök… - The EMBO …, 2005 - embopress.org
The structural basis for the association of eukaryotic and prokaryotic protein receptors and
their triple‐helical collagen ligand remains poorly understood. Here, we present the crystal …