Hepatocyte cell death during liver injury was classically viewed to occur by either
programmed (apoptosis), or accidental, uncontrolled cell death (necrosis). Growing …

Background Biomarkers hold great promise for detecting chronic liver disease without the
use of liver biopsy. Aim To review the usefulness of cytokeratin (CK) 18 fragments, a marker …

Background Lipotoxicity leading to excessive caspase‐mediated apoptosis and
inflammation is believed to drive liver damage in NAFLD. Emricasan is a pan‐caspase …

Background & Aims Cross-sectional studies have associated serum levels of the keratin 18
(K18) fragment with histologic features of liver in individuals with nonalcoholic fatty liver …

Background & Aims Non-alcoholic steatohepatitis is a leading cause of end-stage liver
disease. Hepatic steatosis and lipotoxicity cause chronic necroinflammation and direct …

Caspases play a central role in apoptosis, inflammation, and fibrosis. They produce
hemodynamically active, proinflammatory microparticles that cause intrahepatic …

Noninvasive assessment of disease activity in patients with nonalcoholic fatty liver disease
(NAFLD) and alcoholic liver disease (ALD) is still unsettled, but essential for the evaluation …

Lung cancer is one of the leading causes of death from malignancy worldwide. In particular
small cell lung cancers, which comprise about 15–20% of all lung cancers, are extremely …

The aim of this study was to examine the relationship between the presence of hepatic iron
deposition, apoptosis, histologic features, and serum markers of oxidative stress (OS) and …

Abstract Background & Aims Mortality of patients who develop acute‐on‐chronic liver failure
(ACLF) is unacceptably high but the predominant mode of cell death is unknown. The aim of …