With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most
common primary malignant tumor of the liver in the world. It is also the primary reason for …

Hydrogen sulfide (H 2 S) is the third new gas signaling molecule in the human body after the
discovery of NO and CO. Similar to NO, it has the functions of vasodilation, anti …

Background: Hypoxia is a significant feature of many solid tumors and can activate hypoxia-
inducible factor 1α (HIF-1α)/vascular epidermal growth factor (VEGF) signaling pathway …

Background: The distinctive feature of liver fibrosis is the progressive replacement of healthy
hepatic cells by the extracellular matrix protein, which is abundant in collagen I and III, with …

Chronic liver disease inevitably progresses to liver cirrhosis, significantly compromising
patients' overall survival and quality of life. However, a glimmer of hope emerges with the …

In mammalian systems, hydrogen sulfide (H2S)—one of the three known gaseous signaling
molecules in mammals—has been found to have a variety of physiological functions …

Liver fibrosis is an intrahepatic chronic damage repair response caused by various reasons
such as alcoholic liver, fatty liver, viral hepatitis, autoimmune diseases, etc., and is closely …

MicroRNAs (miRNAs) are the short endogenous non-coding RNAs that regulate the
expression of the target gene at posttranscriptional level through degrading or inhibiting the …

Hepatic encephalopathy (HE) associated with liver failure is accompanied by
hyperammonemia, severe inflammation, depression, anxiety, and memory deficits as well as …

Worldwide, liver fibrosis (LF) causes complications and has an elevated death rate. The
prevalence of mesenchymal stem cell therapy (MSC) is a result of the lack of liver donors. In …