A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

Amyloid diseases are linked to protein misfolding whereby the amyloidogenic protein
undergoes a conformational change, aggregates and eventually forms amyloid fibrils. While …

Flexible polypeptide linkers composed of glycine and serine are important components of
engineered multidomain proteins. We have previously shown that the conformational …

Intrinsically disordered protein (IDP) conformers occupy large regions of conformational
space and display relatively flat energy surfaces. Amyloid-forming IDPs, unlike natively …

Nosocomial infections affect hundreds of millions of patients worldwide each year, and~
60% of these infections are associated with biofilm formation on an implanted medical …

The purpose of this study was to demonstrate a mild enzymatic method for the large-scale
production of nano-scale self-assembled peptide hydrogels (WGP-M, average molecular …

In protein design, the energy associated with a huge number of sequence-conformer
perturbations has to be routinely estimated. Hence, enhancing the throughput and accuracy …

Accurate description of the intrinsic preferences of amino acids is important to consider
when developing a biomolecular force field. In this study, we use a modern energy …

Exploitation of the biotin–streptavidin interaction for advanced protein engineering is used in
many bio-nanotechnology applications. As such, researchers have used diverse techniques …

The role of alpha-synuclein (αS) amyloid fibrillation has been recognized in various
neurological diseases including Parkinson's Disease (PD). In early stages, fibrillation occurs …