The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Background Hepatocellular carcinoma (HCC) is still a major health problem, often
diagnosed at an advanced stage. The multikinase inhibitor sorafenib is to date the sole …

Chronic liver injury, resulted from different etiologies (eg, virus infection, alcohol abuse,
nonalcoholic steatohepatitis (NASH) and cholestasis) can lead to liver fibrosis characterized …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …

The transforming growth factor-beta (TGF-!) belongs to a superfamily of cytokines that act on
protein kinase receptors at the plasma membrane to induce a plethora of biological signals …

Sorafenib is presently the only effective therapy in advanced hepatocellular carcinoma
(HCC). Because most anticancer drugs act, at least in part, through the generation of …

The epithelial-to-mesenchymal transition (EMT) is the development of increased cell
plasticity that occurs normally during wound healing and embryonic development and can …

Liver fibrosis is the pathological consequence of chronic liver diseases, where an excessive
deposition of extracellular matrix (ECM) proteins occurs, concomitantly with the processes of …

NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by
endothelial vascular cells, and affects the cardiovascular system. It plays a major role in …