Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

Many studies have highlighted the importance of the tight regulation of mRNA stability in the
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …

Background The four major RNA adenosine modifications, ie, m 6 A, m 1 A, alternative
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …

All lifeforms have developed highly sophisticated systems equipped to detect altered self
and non-self nucleic acids (NA). In vertebrates, NA-sensing receptors safeguard the integrity …

RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

Modified nucleotides in mRNA are an essential addition to the standard genetic code of four
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …

Cancer was initially considered to be an exclusively genetic disease, but an interplay of
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …

Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …

Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …