Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Heart failure is a global problem with an estimated prevalence of 38 million patients
worldwide, a number that is increasing with the ageing of the population. It is the most …

Engineering cardiac tissues and organ models remains a great challenge due to the
hierarchical structure of the native myocardium. The need of integrating blood vessels brings …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Mesenchymal stromal cells (MSCs) are promising candidates for tissue engineering and
regenerative medicine. The multipotent stem cell component of MSC isolates is able to …

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Summary Background Cardiosphere-derived cells (CDCs) reduce scarring after myocardial
infarction, increase viable myocardium, and boost cardiac function in preclinical models. We …

Heart failure plagues industrialized nations, killing more people than any other disease. It
usually results from a deficiency of specialized cardiac muscle cells known as …

Exosomes are extracellular vesicles of endosomal origin which have emerged as key
mediators of intercellular communication. All major cardiac cell types—including …

Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …