Summary Mac‐1 (CD11b/CD18) is a β2 integrin classically regarded as a pro‐inflammatory
molecule because of its ability to promote phagocyte cytotoxic functions and enhance the …

There is a growing appreciation for the contribution of platelets to immunity; however, our
knowledge mostly relies on platelet functions associated with vascular injury and the …

Systemic lupus erythematosus (SLE), often known simply as lupus, is a severe chronic
autoimmune disease that is characterized by multi-organ and tissue damage and high levels …

Nucleic acid-containing debris released from dead and dying cells can be recognized as
damage-associated molecular patterns (DAMPs) or pattern-associated molecular patterns …

In this review we discuss how sex steroids and prolactin affect regulation and
responsiveness of B and T cells. Sex hormones exert profound effects on several …

To examine the effect of koumine, a Gelsemium alkaloid, on two experimental models of
rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced …

Abstract Alpha-1 antitrypsin (A1AT) is a protease inhibitor in the serum. Its primary function is
to inhibit the activity of a series of proteases, including proteinase 3, neutrophil elastase …

Aims Fcγ receptor I (FcγRI/CD64) that is restrictedly expressed on monocytes and
macrophages, acts as the single high-affinity receptor of immunoglobulin G (IgG) in human …

Autoimmune diseases are conditions caused by an over reactive immune system that
attacks self-tissues and organs. Although the pathogenesis of autoimmune disease is …

Systemic lupus erythematosus (SLE) is an autoimmune disease in which organ damage is
mediated by pathogenic autoantibodies directed against nucleic acids and protein …