The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Autophagy is a tightly regulated catabolic process wherein cells under stress sequester
cytosolic constituents like damaged proteins and organelles in double-membrane vesicles …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of
cells within organisms, respectively, and many stress pathways sequentially elicit …

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …

Autophagy and apoptosis are two important cellular processes with complex and
intersecting protein networks; as such, they have been the subjects of intense investigation …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

Autophagy is a conserved multistep pathway that degrades and recycles damaged
organelles and macromolecules to maintain intracellular homeostasis. The autophagy …

Autophagy is a highly conserved process that maintains cellular homeostasis during
evolution. Autophagy can occur in the form of macroautophagy, microautophagy or …